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Monday, August 17, 2020

Is This Why Trump Keeps Pushing Hydroxychloroquine?

Despite there being no real evidence that hydroxychloroquine is an effective remedy against the coronavirus, Donald Trump keeps pushing it even though the FDA has revoked its emergency use authorization.

The drug is normally used by people suffering from autoimmune diseases such as rheumatoid arthritis and lupus because it suppresses the immune system. So when it was first mentioned as a treatment for Covid-19 it was somewhat plausible that it might be useful in stemming the violent immune system reaction, or cytokine storm, that some Covid patients suffer from.

But it turns out it takes months for hydroxychloroquine to have the desired effect on the immune system

Hydroxychloroquine is a longer acting medication that can take several months to build up in the body and become effective. It can also take several weeks for the medication to “leave the body” or no longer be effective after you have stopped taking it. This is referred to as a medication’s half-life -- the length of time it takes for the medication to reduce to 50% concentration in the body.

So why has Trump been so gung-ho about it? I think it's because of his constant diet of cable TV. For the last 20 years a weight-loss product called Hydroxycut has been hawked incessantly on the late-night TV channels that Trump watches. 

In its ads Hydroxycut uses words like strength, energy, power, and is sold on websites with muscle and strength in the names (like this one). We all know what a sucker Trump is for the magic word strength. Even though this clown is clearly the weakest, most out-of-shape president we've had since FDR and his wheelchair.

Because Trump has heard Hydroxycut being advertised for two decades, and his pea-sized brain thinks all words beginning with the same three syllables are interchangeable, he thinks hydroxychloroquine is a safe and familiar product.

Trump even claimed that he was taking "the hydroxy" (see, only the first three syllables of a word matter), though many doubted he was actually taking hydroxychloroquine. But maybe Trump's doctor was just giving him Hydroxycut. "Sure, Mr. President. This hydroxy is the real stuff!"

The irony, of course, is that Hydroxycut was and is neither safe nor effective. The original formulation included ephedra, a supplement the FDA banned in 2004. Ephedra causes seizures, strokes and fatal heart attacks, and caused the death of pitcher Steve Bechler.

MuscleTech, the company that produced it, covered up research that showed it was ineffective and caused (bum, bum, bum!) cardiac side effects, just like hydroxychloroquine. The company even doctored evidence submitted in an Oklahoma lawsuit.

The company was sold and they came up with a new formulation, keeping the name. But it turns out that one of the ingredients, hydroxycitric acid, causes liver problems, killing one man and requiring at least one liver transplant. So in 2009 the FDA issued a recall order. The company went bankrupt, but they keep on resurrecting this dog of a product.

It was reformulated yet again, with caffeine being the only common ingredient among all the formulations. Which means that Hydroxycut is no more effective than coffee for losing weight.

As much as I like bashing Trump, the real point is that the whole dietary supplement marketplace is a disaster. Companies like MuscleTech can sell worthless garbage as weight-loss and muscle-building supplements, and as long as they weasel-word their ads the FDA can't shut them down until bodies start dropping.

And even then the FDA can't stop them from coming back from the dead with useless zombie products like Hydroxycut.

Now, there are actually drugs out that have proven effective against Covid, including dexamethasone and remdesivir. So what isn't Trump championing those? Does he have stock in MuscleTech, and is he hoping that his followers will starting chugging Hydroxycut since only the first three syllables of a word matter?

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